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LEVOMETHAMPHETAMINE EXPLAINED

Levomethamphetamine is the levorotatory (L-enantiomer) form of methamphetamine. It is a sympathomimetic vasoconstrictor which is active in some over-the-counter nasal decongestant inhalers in the USA.


β€˜Levo’ crosses the blood-brain barrier and acts as a TAAR1 agonist, functioning as a selective norepinephrine releasing agent, so it affects the central nervous system (with no effects on the release of dopamine), although its effects are qualitatively distinct relative to those of dextromethamphetamine.


β€˜Levo’ does not possess the potential for euphoria or addiction that β€˜dextro’ possesses. Among its physiological effects are the vasoconstriction that makes it useful as a nasal decongestant.


The elimination half-life of levomethamphetamine is between 14 and 15 hours, while dextromethamphetamine has a half-life of about 10 hours.



MECHANISM OF ACTION

Levomethamphetamine acts primarily as a norepinephrine releasing agent, with minimal to no dopamine activity. As a result, it lacks the rewarding, euphoric effects typically seen with dextromethamphetamine or illicit stimulants. This makes it effective for nasal decongestion but unsuitable for abuse or recreational use.


KEY DIFFERENCES FROM DEXTROMETHAMPHETAMINE

  • 🚫 No euphoric or stimulant effect
  • 🧠 Limited central nervous system stimulation
  • βœ”οΈ Approved for over-the-counter use
  • ⏳ Longer half-life (~14–15 hours)
  • 🧬 Targets norepinephrine, not dopamine

LIKE ANY DECONGESTANT, ‘LEVO’ SIDE EFFECTS INCLUDE:

  • Hypertension (elevated blood pressure)
  • Tachycardia (rapid heart rate)
  • Nausea
  • Stomach cramps
  • Dizziness
  • Headache
  • Sweating
  • Muscle tension
  • Tremors
  • Anxiety
  • Insomnia
  • Anorexia
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buckshotz68
Member
9 months ago

No Love 4 Levo frfr!

Basketkase11
Member
7 months ago

What’s the purpose behind this non-euphoric headache?